🔬 Advanced Ovarian Cancer: A Meta-Analysis of Survival Without Debulking Surgery🎗️


 Survival in advanced-staged ovarian cancer treated without cytoreductive surgery remains a critical and complex clinical question 🎗️. While cytoreductive (debulking) surgery has long been considered a cornerstone of management, some patients are treated with chemotherapy alone due to frailty, comorbidities, or extensive disease spread. A systematic review and exploratory meta-analysis helps clarify outcomes in this challenging population 📊.

The findings suggest that survival outcomes without surgery are generally lower compared to patients undergoing optimal cytoreduction, highlighting the prognostic importance of tumor burden reduction 🔬. However, in carefully selected patients—especially those unfit for surgery—systemic therapies, including platinum-based chemotherapy and targeted treatments, may still offer meaningful survival benefits 💊. Patient selection, performance status, and molecular characteristics play a decisive role in outcomes.

Importantly, this research emphasizes the need for individualized treatment strategies 🤝. Multidisciplinary evaluation, improved predictive biomarkers, and advances in targeted and immunotherapies could help refine non-surgical pathways in the future 🌍. Understanding survival trends through evidence synthesis supports better decision-making and patient-centered care in advanced ovarian cancer management 💜.

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